Progress in the study of pathogenesis, diagnosis and therapeutics in thyroid hormone insensitivity syndrome
10.3760/cma.j.issn.1000-6699.2014.07.024
- VernacularTitle:甲状腺激素不敏感综合征的发病机制和诊疗进展
- Author:
Huan CHEN
;
Ning WANG
;
Wei CUI
;
Bingyin SHI
- Publication Type:Journal Article
- Keywords:
Thyroid hormone insensitivity syndrome;
Receptors;
Gene mutation
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(7):629-632
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormone insensitivity syndrome is an inherited syndrome characterized by high serum concentrations of thyroid hormone,accompanied by normal or slightly high serum TSH concentration due to the reduced responsiveness of target tissues to thyroid hormone.Thyroid hormone insensitivity syndromes are related to gene mutations of thyroid hormone receptors,thyroid hormone cell transport defect,and thyroid hormone metabolism defect.This article reviews the progress of pathogenesis,diagnosis,and therapeutics of thyroid hormone insensitivity syndrome.
