Intravenous chemotherapy in combination with TACE for the treatment of hepatic metastasis of gastric cancer
10.3760/cma.j.issn.1007-631X.2014.09.010
- VernacularTitle:静脉化疗联合肝动脉化疗栓塞治疗胃癌伴肝转移
- Author:
He HUANG
;
Weijian SUN
;
Mingdong LU
;
Pihong LI
;
Zhonglin NI
;
Wei ZHANG
;
Zhiqiang ZHENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Chemoembolization,therapeutic;
Neoplasm metastasis;
Antineoplastic combined chemotherapy protocols
- From:
Chinese Journal of General Surgery
2014;29(9):693-696
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate efficacy and safety of intravenous chemotherapy combined with TACE in the treatment of gastric cancer with hepatic metastasis.Methods In this study 60 gastric cancer patients with hepatic metastasis were divided into two groups randomly,the trial group (30 cases) took intravenous chemotherapy consisted of docetaxel 60 mg/m2 intravenous drip d1,oxaliplatin 80 mg/m2 intravenous drip d1 followed by 5-fiuorouracil 500 mg/m2 intravenous drip d1-5 after TACE.The control group (30 cases) took the same chemotherapy protocol and one treatment cycle covering 4 weeks.Results The overall response rate in trial group was 53％ and the increase rate of Karnofsky was 70％ while that was 37％ and 40％ respectively in the control group (P ＜ 0.05).The median overall survival of trial group was 13 months and which was 8 months in the control group (P ＜ 0.05),meanwhile the toxicities and side reactions of trial group didn't increase notably.Conclusions Intravenous chemotherapy combined with TACE is safe and more effective in the treatment of gastric cancer with hepatic metastasis.
