Diagnostic value of four serum tumor markers in lung cancer
10.3969/j.issn.1673-4130.2014.18.017
- VernacularTitle:血清四项肿瘤标志物检测对肺癌的诊断价值
- Author:
Fengli WU
;
Xiaoguang MA
- Publication Type:Journal Article
- Keywords:
lung cancer;
tumor markers;
neuron specific enolase;
carcinoembryonic antigen;
cytokeratin-19 fragments;
squamous cell carcinoma antigen
- From:
International Journal of Laboratory Medicine
2014;(18):2462-2463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of serum tumor markers carcinoembryonic antigen (CEA) ,neuron spe-cific enolase(NSE) ,cytokeratin-19 fragments(CYFRA21-1) ,squamous cell carcinoma antigen(SCCA)in the lung cancer .Methods By using electro chemiluminescence immunoassay ,the concentrations of CEA ,NSE ,CYFRA21-1 and SCCA were determined in 98 cases of lung cancer and 30 cases of healthy control group ,and the positive rate ,sensitivity ,specificity ,accuracy were calculated .Re-sults In different lung cancer pathological groups ,the concentrations of the 4 serum tumor markers were significantly higher than the control group(P<0 .05) .CEA had the highest diagnostic sensitivity for detecting adeno carcinoma ,NSE had the highest diag-nostic sensitivity for detecting small cell lung cancers ,CYFRA21-1 had the highest diagnostic sensitivity for detecting squamous carcinoma .The combined tests of four serum tumor markers had higher diagnostic sensitivity and accuracy than single test for lung cancers .Conclusion The four serum tumor markers are valuable in the pathological classification ,diagnosis and differential diagno-sis of lung cancer .The diagnostic sensitivity and the accuracy are obviously higher in combined tests .
