Hepcidin measurement in the differential diagnosis of iron deficiency anemia and anemia of chronic disease
10.3969/j.issn.1673-4130.2014.18.020
- VernacularTitle:铁调素检测在缺铁性贫血与慢性贫血鉴别诊断中的价值
- Author:
Tingting SHU
- Publication Type:Journal Article
- Keywords:
hepcidin;
iron deficiency anemia;
anemia of chronic diseases;
differential diagnosis
- From:
International Journal of Laboratory Medicine
2014;(18):2469-2470
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of hepcidin measurement in differential diagnosis of iron deficiency anemia(IDA) and anemia of chronic diseases(ACD) .Methods Serum hepcidin was measured by using ELISA .Serum iron(SI) and total iron binding capacity(TIBC) were determined by using Ferro zine colorimetric method .Results Hepcidin expression increased in ACD group (P<0 .05) ,but decreased in IDA group(P<0 .05) .The area under the curve of ROC for hepcidin ,SI and TIBC were 0 .97 ,0 .66 and 0 .85 respectively .Conclusion Hepcidin is a simple and safe indicator in differential diagnosis of IDA and ACD ,and its diagnos-tic accuracy is better than SI and TIBC .
