The detection of viral and atypical pathogens in children with acute respiratory infection
10.3969/j.issn.1673-4130.2014.18.004
- VernacularTitle:儿童急性呼吸道感染病毒和非典型病原体的检测
- Author:
Zegang WU
;
Yan LI
;
Jian GU
- Publication Type:Journal Article
- Keywords:
acute respiratory infections;
pathogens;
epidemiology;
children
- From:
International Journal of Laboratory Medicine
2014;(18):2432-2434
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigete the viral and atypical pathogens in children with acute respiratory infection (ARI) .Methods A total of 17 048 serum samples were collected from children ,who were intended to diagnose as ARI .Indirect immunofluores-cence assays were performed to detect IgM antibodies against 9 common pathogens ,including mycoplasma pneumonia(MP) ,influen-za virus B(FluB) ,respiratory syncytial virus(RSV) ,parainfluenza virus(PIV) ,adenovirus(ADV) ,influenza A virus(FluA) ,legio-nella pneumophila(LPN) ,coxiella burnetii(COX) ,chamydophila pneumonia(CPn) .Results The total detection rate of the 9 patho-gens was 60 .24% (10 269/17 048) .The detection rate of MP was 47 .78% (8 146/17 048) which was the highest ,followed by FluB which was 30 .87% (5 262/17 048) .The detection rate of MP kept at a high level through the whole year ;FluB appeared a little popular in the summer ,winter and spring ;RSV had higher detection rate in winter and spring ;ADV had higher detection rate in spring ;FluA appeared a little popular in spring and summer ;PIV and LPN didn′t show any seasonal change .There were significant differences in the detection rates of ADV ,CPn ,FluA ,FluB ,LPN ,MP ,PIV and RSV among different age groups (P< 0 .05) .In mixed infection with 2 kinds of pathogens ,MP+FluB was the most common pattern which accounted for 39 .58% of mixed infec-tion .In mixed infection with 3 kinds of pathogens ,MP+FluB+RSV was the most common pattern which accounted for 13 .68% .In mixed infection with 4 kinds of pathogens ,MP+ FluB+ RSV+ PIV was the most common pattern which accounted for 3 .84% . Other mixed infection pattern was rare .Conclusion The most common pathogens causing ARI in children of Wuhan were MP ,FluB and RSV .The detection rate of each pathogen displayed specific seasonal variations and variations among different age groups . Mixed infections were more common than single infections ,and the most common pattern was MP+ FluB .
