Clinical significance of plasma Hcy hs-CRP and vWF determination in patients with acute cerebral infarction
10.3969/j.issn.1673-4130.2014.18.009
- VernacularTitle:急性脑梗死患者血浆 Hcy hs-CRP vW F检测的临床意义
- Author:
Qi ZHANG
;
Jie GENG
;
Jianguo ZHAO
;
Xueqi ZHANG
;
Guosen LI
;
Wei YAN
;
Genli ZHANG
- Publication Type:Journal Article
- Keywords:
acute cerebral infarction;
homocysteine;
high sensitivity c-reactive protein;
von Willebrand factor
- From:
International Journal of Laboratory Medicine
2014;(18):2444-2445
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between plasma homocysteine (Hcy) and high sensitivity C-reactive protein (hs-CRP) ,Hcy and von Willebrand factor(vWF) in patients with acute cerebral infarction ,and to analyze their clinical significance . Methods 150 patients with acute cerebral infarction were enrolled in the study ,and were divided into 3 groups according to their plasma Hcy concentrations .Meanwhile 50 healthy people were recruited as control group .Plasma hs-CRP ,vWF and Hcy concentra-tions were determined and compared between groups .Then data correlation analysis was performed .Results In patients with acute cerebral infarction plasma hs-CRP ,vWF and Hcy concentrations were significantly higher than those in healthy control group (P<0 .05) .Plasma Hcy concentrations in patients with acute cerebral infarction were positively correlated with plasma hs-CRP and vWF concentrations .Conclusion Hs-CRP ,vWF and Hcy are biomarkers of endothelial injury ,the combined detection of the three indica-tors might contribute to the early diagnosis and treatment of acute cerebral infarction .
