The clinical significance of immature reticulocyte fraction during radiotherapy and chemotherapy in patients with tumor
10.3969/j.issn.1673-4130.2014.18.014
- VernacularTitle:未成熟网织红细胞比率测定在肿瘤放化疗中的临床意义
- Author:
Linhai WANG
- Publication Type:Journal Article
- Keywords:
reticulocyte;
immature reticulocyte fraction;
leukocytes;
neutrophils;
tumor radiotherapy and chemotherapy
- From:
International Journal of Laboratory Medicine
2014;(18):2455-2456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of peripheral blood parameters before and after radiotherapy and chemothera-py ,and establish an early index that can reflect the suppression and recovery of the bone marrow hematopoietic function in patients with tumor .Methods The white blood cell(WBC) ,neutrophils(NEU) ,the percentage of reticulocyte(Ret% ) and the immature re-ticulocyte fraction(IRF) of peripheral blood were detected by Sysmex XT-2000i automatic blood cell analyzer before and after radio-therapy and chemotherapy in 50 patients with tumor .Results Bone marrow function was suppressed after radiotherapy and chemo-therapy .Compared with the value before radiotherapy and chemotherapy ,IRF and Ret% were significantly decreased on the 3rd day after therapy which was 3 days earlier than the change of WBC and NEU ,the difference was statistically significant (P<0 .05) ,and compared with the value of the 10th day ,IRF began to rebound on the 15th day which was 5 days earlier than the change of Ret%and NEU ,the difference was statistically significant (P<0 .05) .Conclusion IRF can be served as an early and sensitive indicator in monitoring the suppression and recovery of bone marrow hematopoietic function in the patients with tumor during radiotherapy and chemotherapy .
