Values of serum VEGF, CEA, CA19-9 and SF for predicting the efficacy to chemotherapy in advanced gastric cancer
10.3969/j.issn.1673-4130.2014.18.016
- VernacularTitle:血清 VEGF CEA CA19-9和SF水平变化在晚期胃癌患者化疗疗效评估中的价值
- Author:
Jinhua GU
;
Tao GU
;
Lina ZHOU
;
Liqiang WANG
;
Ling CHEN
- Publication Type:Journal Article
- Keywords:
gastric cancer;
serum;
tumor marker;
chemotherapy
- From:
International Journal of Laboratory Medicine
2014;(18):2459-2461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the values of serum vascular endothelial growth factor (VEGF) ,carcinoembryonic antigen (CEA) ,carbohydrate antigen 19-9 (CA19-9) and ferritin (SF) determination in assessing the efficacy of chemotherapy in patients with advanced gastric cancer .Methods Wedetermined the concentrations of serum VEGF ,CEA ,CA19-9 and SF for 85 patients with advanced gastric cancer ,before and after 1 cycles of chemotherapy and evaluated the the effect of chemotherapy after 2 cycle of chemotherapy .Results In effective group ,serum concentrations of VEGF ,CEA ,CA19-9 and SF significantly decreased after chem-otherapy cycle(P< 0 .05) ,serum VEGF and CEA concentrations significantly increased in progress group (P< 0 .05) ,serum VEGF ,CEA ,CA19-9 and SF concentrations in stable group and serum CA19-9 and SF concentrations in progress group did not change significantly(P> 0 .05) ,compared with those before chemotherapy cycle .Multiple regression analysis showed that serum CEA ,VEGF ,CA19-9 concentration changes correlated with chemotherapy efficiency ,while serum SF didn′t(t=1 .58 ,P=0 .119) . Conclusion Serum CEA ,VEGF ,CA19-9 concentration changes associated with gastric cancer chemotherapy efficiency ,which help predict the efficiency of chemotherapy .
