Early anticoagulation therapy after splenectomy plus devascularization in the prevention of thrombosis
10.3760/cma.j.issn.1007-631X.2014.08.021
- VernacularTitle:脾切除断流术后早期抗凝治疗对患者凝血功能的影响
- Author:
Qiuxue ZHANG
;
Zhiquan ZHANG
;
Ruhai LIU
;
Tiegong WANG
;
Lei ZHANG
;
Xin CHEN
- Publication Type:Journal Article
- Keywords:
Hypertension,portal;
Venous thrombosis;
Anticoagulants;
Blood coagulation indexes
- From:
Chinese Journal of General Surgery
2014;29(8):634-636
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of early anticoagulation therapy on the blood coagulation in patients undergoing splenectomy plus devascularization.Methods Clinical data of 106 patients in Cangzhou Central Hospital from June 2000 to December 2012 were reviewed.Beginning 24 h after surgery,low molecular dextran 500 ml + ligustrazine 160 mg,once a day for 1 week,and after 48 h low molecular heparin calcium at 4 250 U to 4 500 U was given every 12 h for 7 to 14 d.Blood coagulation was tested on day 3,5,7,10 and 14,ultrasound 1-2 times a week was taken for detection of portal venous thrombosis.Results The incidence of portal thrombosis was 7.5％ (8/106).APTT prolonged during 7-14 d.Prothrombin time (PT),thrombin time (TT) and fibrinogen (FIB) decreased,but all the changes were not statistically significant when compared with the normal values(P ＞0.05).Anticoagulant treatment did not cause bleeding complications in this series.Conclusions Postoperative application of low molecular heparin calcium anticoagulant therapy is effective in the prevention of portal thrombosis and safe in terms of coagulation when started early in patients undergoing splenectomy.
