Chemoradiotherapy for unresectable pancreatic cancer patients after percutaneous transhepatic cholangiodrainage
10.3760/cma.j.issn.1007-631X.2014.08.019
- VernacularTitle:胰腺癌梗阻性黄疸患者胆道内支架置入术后放化疗疗效分析
- Author:
Jie WU
;
Lei SONG
;
Danyi ZHAO
;
Bing GUO
;
Jing LIU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Jaundice,obstructive;
Drainage;
Chemoradiotherapy
- From:
Chinese Journal of General Surgery
2014;29(8):626-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of chemoradiotherapy in patients with unresectable pancreatic cancer who were previously treated with PTCD.Methods From September 2005 to December 2012,47 unresectable pancreatic cancer patients with obstructive jaundice were enrolled in this study.They were divided into two groups.21 patients received after PTCD chemotherapy or radiation,or chemoradiotherapy.26 patients in support care group received only nutrition,analgesia and other related support treatment.Survival analysis was performed with Kaplan-Meier statistics.Differences in survival between the groups were assessed for statistical significance with the log-rank test.Results The median overall survival time of patients after PTCD was 7.19 months.The median overall survival time of chemoradiation group was 9.07 months,which was higher than that of support care group (5.52 months),P=0.017.12 patients received single therapy (either chemo or radiation),and 9 patients received chemoradiotherapy.The median overall survival times were 8.31 months and 11.15 months,respectively (P =0.325).Conclusions Post PTCD chemoradiotherapy helps prolong the survival time in unresectable pancreatic cancer patients.
