Value of serum lactate dehydrogenase and vascular endothelial growth factor in evaluating short-term efficacy of TACE
10.3969/j.issn.1000-8179.20140889
- VernacularTitle:血清乳酸脱氢酶血管内皮生长因子对TACE近期疗效的评估价值
- Author:
Binbin QIAO
;
Changsheng SHI
;
Xixiang YU
;
Shuting WANG
;
Chijin XIAO
- Publication Type:Journal Article
- Keywords:
primary liver cancer;
transcatheter arterial chemoembolization;
lactate dehydrogenase;
vascular endothelial growth factor;
efficacy
- From:
Chinese Journal of Clinical Oncology
2014;(15):964-967
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the assessed value of serum lactate dehydrogenase (LDH) and vascular endothelial growth factor (VEGF) for short-term efficacy of transcatheter arterial chemoembolization (TACE). Methods: Serum concentrations of LDH and VEGF from 70 patients with primary liver cancer on the 1st day before therapy and the 3rd, 7th, 14th, and 21st day after TACE ther-apy was determined. The benefit group includes complete remission, partial remission, and stable disease, while the invalid group in-cludes only disease progression. Results:The serum levels of LDH and VEGF in the invalid group were significantly higher than those in the benefit group on the 14th and 21st days after TACE (P<0.05). The percentage changes of the serum concentrations of LDH and VEGF in the invalid group were higher than those in the benefit group on the 21st day after TACE. Percentage changes on the 21st day after TACE were drawn into the ROC curve;the areas under the curve were 65.9%and 85.5%. The optimal cutoff points of LDH and VEGF, which correspond to the Youden index, were 0.272 and 0.745, respectively. Conclusion:The expression levels of VEGF and LDH can be used to assess the short-term efficacy of TACE. A lower expression level corresponds to short-term efficacy.
