Research progress in relationship between phospholipase A2 and tumorigenesis
10.3969/j.issn.1000-8179.20140765
- VernacularTitle:磷脂酶A2与肿瘤发生相关性研究进展
- Author:
Xuehui ZHANG
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
phospholipase A2;
tumor;
detection
- From:
Chinese Journal of Clinical Oncology
2014;(15):1007-1010
- CountryChina
- Language:Chinese
-
Abstract:
Phospholipase A2 (PLA2) has been a recent concern given the high incidence of tumors. Increasing amounts of re-search report that PLA2 is an inflammatory factor that is closely associated with tumor incidence. Moreover, it displays high specificity, minimal biological variation, is rarely affected by other inflammation markers, and has a definite relation with the differentiation in tu-mors of the digestive tract, such as intestinal and gastric cancers. PLA2 is also related to the invasion mechanisms, metastasis, and apop-tosis of tumors. In addition, PLA2 can be applied to the scoring and to the clinical and medicinal treatment of the Gleason tumor, which is found in prostatic cancers of the genital system. It is also closely related to the proliferation and infiltration of ovarian cancer cells. Therefore, PLA2 can be used as a new test index for the clinical diagnosis and treatment of tumors, which may generate a new research direction with respect to the forecasting of tumor incidence and progression. The bionomics of PLA2 facilitate the use of inflammatory factors in the detection procedures utilized by clinical laboratories, which can monitor the conditions of cancer patients in advance and effectively customize treatment regimens for such patients.
