Research progress on the anti-cancer effect and mechanisms of the natural tanshinones
10.3969/j.issn.1001-1978.2014.08.002
- VernacularTitle:丹参酮类抗肿瘤作用与机制研究进展
- Author:
Wenhui HAO
;
Wenwen ZHAO
;
Xiuping CHEN
- Publication Type:Journal Article
- Keywords:
tanshinone ⅡA;
cryptotanshinone;
tanshinone I;
dihydrotanshinone I;
cancer;
effect and mechanisms;
progress
- From:
Chinese Pharmacological Bulletin
2014;(8):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
Tanshinones are a large class of hydrophobic natural products isolated from traditional Chinese herb Salvia miltiorrhiza Bunge and related plants. Tanshinones include tanshinone ⅡA, cryptotanshinone, tanshinone I, dihydrotanshinone, and so on. Both the tanshinones and the salvianolic acids have been identi-fied as the characteristic and main active ingredients of Salvia miltiorrhiza Bunge with cardiovascular protective activities. Ac-cumulated data in recent years have revealed that tanshinones possess remarkable anti-cancer activities both in vivo and in vitro. In this review, we summarize the latest progress of the an-ti-cancer effect and the underlying mechanisms of tanshinones, particularly with emphasis on tanshinone ⅡA, which might pro-vide reference for the further research and development of these compounds.
