Impact of ABCB1 gene polymorphism on opioid dependence and analgesic tolerance
10.3969/j.issn.1001-1978.2014.08.005
- VernacularTitle:ABCB1基因多态性对阿片类药物依赖和镇痛耐受的影响及机制
- Author:
Chenling GAN
;
Zhongguo CHEN
;
Ling HE
;
Jinggen LIU
- Publication Type:Journal Article
- Keywords:
drug dependence;
ABCB1;
gene polymorphism;
3435C>T;
analgesic tolerance;
MMT
- From:
Chinese Pharmacological Bulletin
2014;(8):1055-1058
- CountryChina
- Language:Chinese
-
Abstract:
Drug dependence has been a hot topic in neuroscience research due to its complicated pathogenesis. Recently, huge scientific efforts have been continuously put into understanding the association between drug dependence and polymorphism in ATP-binding cassette subfamily B member 1 transporter ( ABCB1 ) gene, especially a mutation in exon 26 at position 3435 (3435C>T). This article reviews the relationship between opioid dependence and analgesic tolerance and ABCB1 gene pol-ymorphism, which will shed light on the underlying mechanisms of drug dependence and optimal MMT programs for individuals.
