Effects of echinacoside on striatal and hippocampus extracellular fluid of monoamine neurotransmitter in Parkinsonˊs disease rats
10.3969/j.issn.1001-1978.2014.08.019
- VernacularTitle:松果菊苷对帕金森病大鼠纹状体及海马细胞外液中单胺类神经递质的影响
- Author:
Wanxin ZHANG
;
Jingyi MA
;
Hong CHEN
;
Yong JIANG
;
Pengfei TU
;
Hui DING
- Publication Type:Journal Article
- Keywords:
echinacoside;
Parkinsonˊs disease;
stria-tum;
hippocampus;
microdialysis;
monoamine neuro-transmitter
- From:
Chinese Pharmacological Bulletin
2014;(8):1131-1136
- CountryChina
- Language:Chinese
-
Abstract:
Aim Tostudytheeffectsofechinacoside on striatal and hippocampus extracellular fluid of mono-amine neurotransmitter in Parkinsonˊs disease rat, and discuss the possible mechanism of the ECH effect on brainprotection.Methods Doublepointinjectionof 6-hydroxy dopamine damaged was adopted to make PD model, the corresponding drugs or normal saline were intraperitoneally injected for 4 consecutive weeks, mi-cro-dialysis program in double targets was taken after treatment, the dialysate was injected into HPLC-EDC, and striatal and hippocampus extracellular fluid of DA, DOPAC, HVA, NA, 5-HT levels of each group were measured. Results Compared with control group, striatal and hippocampus extracellular fluid of DA, DOPAC, HVA, NE, 5-HT levels were significantly re-duced in model group ( P <0. 01 ); compared with model group, striatal and hippocampus extracellular fluid of DA, DOPAC, HVA, NE, 5-HT levels were significantly increased in treatment group ( P <0 . 05 , P<0. 01 ) , and the content of five kinds of substances in ECH high dose group was similar to that in MD group.Conclusion ECHcouldincreaseextracellular monoamine neurotransmitters in striatum and hippo-campus, ECH has a therapeutic effect on PD, and echinacoside is possible mechanisms of the brain pro-tective effect of PD rats.
