Research progress in association between the Kruppel-like factor 9 and tumor development
10.3760/cma.j.issn.1673-422X.2014.07.001
- VernacularTitle:转录因子KLF9与肿瘤的研究进展
- Author:
Pengliang SHEN
;
Guowei SHI
- Publication Type:Journal Article
- Keywords:
Neoplasticprocesses;
Geneexpression;
Cellapoptosis;
Kruppel-liketranscriptionfactors
- From:
Journal of International Oncology
2014;(7):481-484
- CountryChina
- Language:Chinese
-
Abstract:
KLF9(Kruppel-likefactor9)isthetranscriptionfactorthatcanbindGC-richsitesthrough three C2H2-type zinc fingers and can regulate diverse biological processes,including cell proliferation,apopto-sis and the development of the organ.KLF9 is downregulated in some tumor specimens and tumorous cell lines relative to the normal samples and cell lines and plays an important role in the growth of cancer cells.Similar with the other KLF numbers,KLF9 could affect the development of tumors,especially for the endocrine-related cancers through multiple signaling pathways and interventions with other proteins.
