Advances in the research on epigenetic regulation factors-SNF5 and EZH2 in the carcinogenesis and progress of different tumors
10.3760/cma.j.issn.1673-422X.2014.07.003
- VernacularTitle:表观遗传调控因子SNF5和EZH2在肿瘤发生发展中的研究进展
- Author:
Shaohua WU
;
Lizhu SHAN
;
Huaqing WANG
- Publication Type:Journal Article
- Keywords:
Epigenesis,genetic;
Neoplasms;
Genesilencing;
EZH2
- From:
Journal of International Oncology
2014;(7):488-492
- CountryChina
- Language:Chinese
-
Abstract:
EpigeneticsreferstoheritablealterationsingeneexpressionthatdonotinvolvetheDNA coding sequence itself.Epigenetic regulation plays an important role in gene expression,DNA replication,rep-aration and reconstitution. Thus, the abnormity of epigenetic regulation may lead to different diseases, especially cancer.SNF5 ,which can suppress tumor significantly,is one of the core components of SWI/SNF chromosome remodeling complexes.EZH2,a histone methyltransferase,is closely and complicatedly related to cancer and has significant effect on tumorigenesis.There are many studies reporting the effects of epigenetic regulation factors-SNF5 and EZH2 on different tumors as well as the interrelation at present.In the present paper,the advances in the research on these two epigenetic regulation factors in the carcinogenesis are reviewed.
