Research progress of kinetochore protein CENP-F in malignant tumor
10.3760/cma.j.issn.1673-422X.2014.07.006
- VernacularTitle:着丝粒蛋白F与恶性肿瘤的关系
- Author:
Jin ZHENG
;
Yingcheng LIN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Prognosis;
CentromereproteinF
- From:
Journal of International Oncology
2014;(7):500-502
- CountryChina
- Language:Chinese
-
Abstract:
CENP-Fisacell-cycledependentkinetochoreprotein,whoseexpressionandlocalization patterns are regulated in a cell cycle-dependent manner.CENP-F plays an important role in the development and progress of malignant tumor.The expression of CENP-F is up-regulated in many tumors.It serves as an important marker in cell proliferation.Studies have demonstrated that CENP-F is involved in tumor genesis, progress,invasiveness,relapse and prognosis.CENP-F might be a valuable prognostic marker and potential therapy target in cancer treatment.
