Research progress of cell division cycle 25 homolog C and tumor radiosensitivity

VernacularTitle:细胞分裂周期蛋白25同源蛋白C与肿瘤放疗敏感性
Author: Yachao YIN ; Duojie LI
Publication Type:Journal Article
Keywords: Cdc25phosphatases; Radiationtolerance; Neoplasms; Cellcycle
From: Journal of International Oncology 2014;(7):511-514
CountryChina
Language:Chinese
Abstract: AsoneoftheCdc25phosphatasefamilymembers,Cdc25Cplaysanimportantroleinregu-lating mitosis of eukaryotic cells.In eukaryotic cells,CDK1-cell cycle protein B (CyclinB)compound mainly control the process of G2-M.The activity of Cdc25 C is the key in cell cycle into M phase.It activates CDK1-cyclinB complexes to promote cells from G2 to M phase .Improving Cdc25 C activity can promote the G2-M phase transition,and remove the G2-M phase retardation induced by ionizing radiation,preventing the damaged DNA from repaired into the phase of cell division,resulting in cell death caused by excessive cell proliferation, thus enhance radiosensitivity.