The research on inflammatory reaction and differential expression of microRNAs in lung caner
10.3760/cma.j.issn.1673-422X.2014.07.011
- VernacularTitle:炎症反应与微小RN A差异性表达在肺癌中的研究进展
- Author:
Dongxu JIN
;
Guangqiang ZHAO
;
Yunchao HUANG
;
Hu LI
- Publication Type:Journal Article
- Keywords:
Lungneoplasms;
Systemicinflammatoryresponsesyndrome;
MicroRNAs;
STAT3tran-scription factor;
NF-κB
- From:
Journal of International Oncology
2014;(7):518-520
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAisatypeofsingle-strandednon-codingRNA,directlybondingtothecomplemen-tary target gene mRNA.That leads to the inhibition of mRNA translation of the target molecule in order to reduce expression of the target gene.MicroRNAs are not only involved in the regulation of inflammatory reac-tion,but also play important roles in the formation of neoplasm.The researches showing that the inflammatory reaction interacting with miRNAs results in the differential expressions of microRNAs in lung cancer have been widespreadly concerned.Along with the deepening of the research on the mechanisms of inflammatory reaction and differential expression of microRNAs,it will provide new strategies for the prevention,diagnosis and treat-ment of lung cancer.
