Advance of targeted therapy for gastric cancer
10.3760/cma.j.issn.1673-422X.2014.07.012
- VernacularTitle:胃癌靶向治疗的研究进展
- Author:
Kewei XUE
;
Guixin LI
;
Gongai WANG
;
Yu JIANG
- Publication Type:Journal Article
- Keywords:
Stomachneoplasms;
Receptor,epidermalgrowthfactor;
Enzymeinhibitors;
Targetedtherapy
- From:
Journal of International Oncology
2014;(7):520-522
- CountryChina
- Language:Chinese
-
Abstract:
Inrecentyearsmanytargetedagentstreatinggastriccancerhavebeenevaluatedinclinical studies.Trastuzumab,an anti-HER-2 monoclonal antibody,has shown activity against HER-2-positive gastric cancer and become the first targeted agent approved in gastric cancer.Drugs targeting epidermal growth factor receptor,including monoclonal antibody and tyrosine kinase inhibitor,bring survival benefit to patients with gastric cancer.Addi tionally,vascular endothelial growth factor inhibitors are also under investigation.Other targeted agents are in preclinical or early clinical development,such as m-TOR inhibitors and c-MET inhibi-tors.
