The occurrence,development and metastasis in bone neoplasms
10.3760/cma.j.issn.1673-422X.2014.07.016
- VernacularTitle:骨肿瘤的发生发展及转移
- Author:
Cheng YANG
;
Hongwei SU
;
Huiwen REN
;
Hongwei LI
- Publication Type:Journal Article
- Keywords:
Boneneoplasms;
Osteosarcoma;
Ewingsarcoma;
Neoplasmmetastasis
- From:
Journal of International Oncology
2014;(7):533-536
- CountryChina
- Language:Chinese
-
Abstract:
Bonetumorisonekindofmalignanttumorwhichthreatslifeamongchildrenandadoles-cent.Osteosarcoma (OS ) and Ewing sarcoma (ES ) have been paid much attention by medical community because of their complex occurrence,development,metastasis mechanism and poor prognosis.The research showed that activation of protooncogene and mutation of suppressor gene,absence of apoptosis signal and hypox-ia-inducible factor (HIF)all participated in the occurrence,development and metastasis of OS and ES.It is suggested that clarified pathomechanism of bone tumors could provide more effective therapeutic strategies and lower the mortality of patients.
