Research of aromatase inhibitor-associated arthralgia
10.3760/cma.j.issn.1673-422X.2014.07.017
- VernacularTitle:芳香化酶抑制剂相关骨关节疼痛研究进展
- Author:
Xinyue DONG
;
Liping FANG
;
Kui JIANG
- Publication Type:Journal Article
- Keywords:
Pain;
Breastneoplasms;
Aromataseinhibitors
- From:
Journal of International Oncology
2014;(7):536-540
- CountryChina
- Language:Chinese
-
Abstract:
Aromataseinhibitors(AI)aretheleadingcarefortheadjuvanttreatmentofhormone responsive carcinoma of the breast as demonstrated in a number of large international phase III randomised tri-als.Aromatase inhibitor-associated arthralgia (AIA )was a somewhat unexpected side effect of this class of agents and has proven to be potentially problematic in clinical practice.The pathogenesis of AIA is not very clear currently,with the cause of most research focusing on estrogen deprivation,immune abnormalities,tenosy-novial changes and joint effusions.It is extremely urgent that we evaluate this syndrome and select appropriate therapeutic strategies to reduce the incidence of AIA,thereby improving breast cancer-related outcomes.
