Pemetrexed in combination with cisplatin in the treatment of advanced breast cancer application
10.3760/cma.j.issn.1673-422X.2014.07.019
- VernacularTitle:培美曲塞联合顺铂在晚期乳腺癌中的应用
- Author:
Lijuan YUE
;
Xinli HOU
;
Hui XUE
;
Ling XUE
;
Xiang GAO
;
Yong SHEN
;
Liang YUAN
;
Jingjing ZHANG
;
Hongcai ZHU
- Publication Type:Journal Article
- Keywords:
Cisplatin;
Breastneoplasms;
Therapeuticuses
- From:
Journal of International Oncology
2014;(7):545-548
- CountryChina
- Language:Chinese
-
Abstract:
Objective Tostudyrecentclinicalefficacyandadversereactionsofpemetrexedincombi-nationwithcisplatininthetreatmentofadvancedbreastcancer.Methods Usingenvelopesandrandomlythe patients were dividing into treatment group and control group.The treatment group with 1 8 cases of advanced breast cancer were treated with pemetrexed and cisplatin while in the control group ,23 cases advanced breast cancer patients were treated with gemcitabine and cisplatin with 21 days as a cycle.The efficacy and adverse re-actions were determined according to the WHO on Response Evaluation Criteria in Solid Tumors therapy and chemotherapytoxicityevaluationcriteria.Results Tumorcontrolrateinthetreatmentgroupwas83.3%(1 5/1 8),while in the control group was 78.3%(1 8/23 ),and the difference was not statistically significant (χ2 =0.000 94,P>0.05);while the adverse reactions differenced between the treatment group and the con-trol group were statistically significant(bone marrow suppression χ2 =9.23;fatigue χ2 =4.96;nausea and vomi-tingχ2=4.98;diarrheaχ2=4.45;skinrashχ2=5.03,P<0.05).Conclusion Pemetrexedcombinedwith cisplatin in patients with advanced breast cancer has a good effect,and the adverse reaction is low.
