The study of the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris
10.3760/cma.j.issn.1008-1372.2014.07.012
- VernacularTitle:UA 患者血清血管生成因子的改变研究
- Author:
Fang ZHANG
;
Yulin CHEN
;
Yuerong JIANG
- Publication Type:Journal Article
- Keywords:
Angina,unstable;
Vascular endothelial growth factor A/blood;
Angiopoietins/blood;
Fibroblast growth factor 2/blood;
Diabetes mellitus
- From:
Journal of Chinese Physician
2014;(7):901-903
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in serum concentrations of angiogenic factors in patients with unstable angina pectoris.Methods A total of 60 patients with unstable angina pectoris was eligible for study and divided into diabetes group ( A group, n =20) and non-diabetes group (B group, n =40).Another 30 general-matched healthy subjects from medical examination center were enrolled as control group .Serum samples were collected , and serum concentrations of vascular endothelial growth factor (VEGF), angiopoietin-1, angiopoietin-2, angiogenin, angiostatin, basic fibroblast growth factor (bFGF), and platelet-derived growth factor-BB ( PDGF-BB) were measured by cytokine array technology and compared between the groups .Results Compared with the control group, the serum concentrations of VEGF [(325.2 ±210.1)pg/ml] and angiopoietin-2 [(3031.3 ±1865.5)pg/ml] were sig-nificantly increased in patients with unstable angina pectoris (both P <0.05).Whereas,no significant differences in serum concentra-tions of angiogenin,angiopoietin-1,angiostatin,bFGF,and PDGF-BB were detected between control group and patient groups .There were no significant differences in serum concentrations of above all 7 biomarkers between diabetes group and non-diabetes group .Con-clusions Serum concentrations of VEGF and angiopoietin-2 were increased in patients with unstable angina pectoris ,and diabetes didn't affect the increases in serum concentrations of VEGF and angiopoietin-2 caused by unstable angina pectoris .
