The use of the increased IL-27 expression as a diagnostic marker in the serum of hepatocellular carcinoma patients
10.3760/cma.j.issn.1008-1372.2014.07.013
- VernacularTitle:IL-27在肝癌患者血清中表达增高对肝癌诊断的研究
- Author:
Shasha FAN
;
Rong LI
;
Fengsheng CHEN
;
Junyi ZHANG
;
Rongcheng LUO
- Publication Type:Journal Article
- Keywords:
Liver neoplasms/diagnosis;
Early diagnosis;
Alpha-fetoproteins;
Interleukins/blood;
Logistic models
- From:
Journal of Chinese Physician
2014;(7):904-906
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of IL-27 in hepatocellular carcinoma ( HCC) in the early stage , and to compare it with alpha-fetoprotein ( AFP) in diagnostic performance .Methods Enzyme-linked immunosorbent assay was used to detect the serum level of IL-27 in the HCC group and control group .Receiver operator characteristic ( ROC) curve was used to ana-lyze two indicators and the logistic regression model predicted value ( PRE) was obtained .Results The study indicated the concentra-tion of IL-27 in HCC group [(364.19 ±177.55)pg/ml] was significantly higher than the control group [(255.49 ±94.33)pg/ml], the area under the curve (AUC) of IL-27 and AFP were (0.804) and (0.818), respectively.Logistic regression obtained the regres-sion model PRE that contains AFP and IL-27, with a predicted area under the ROC curve for HCC (0.901), while the diagnostic sen-sitivity (84.8%) and specificity (96.7%) were significantly higher than the capability of individual diagnosis of each indicator .Con-clusions In this study we obtained the model which can be used for clinical diagnosis of hepatocellular carcinoma in future .
