Metabolic characteristic and insulin resistance in newly diagnosed type 2 diabetes patients with nonalcoholic fatty liver disease
10.3760/cma.j.issn.1008-1372.2014.07.017
- VernacularTitle:新诊断2型糖尿病合并非酒精性脂肪肝临床特征及胰岛素抵抗特点分析
- Author:
Zhihua SUN
;
Liping CUI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2/complications;
Fatty liver/complications;
Insulin resistance;
Body mass index;
Blood pressure;
Blood glucose
- From:
Journal of Chinese Physician
2014;(7):916-918
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate metabolic characteristics and insulin resistance in newly diagnosed type 2 diabetes pa-tients with nonalcoholic fatty liver disease .Methods Two hundred patients with newly diagnosed type 2 diabetes mellitus including 140 with nonalcoholic fatty liver disease (NAFLD) (NAFLD group) and 60 without NAFLD (non-NAFLD group) were recruited. Metabolic characteristic were measured and recorded .homeostasis model assessment insulin resistance ( HOMA-IR) index and HOMA-C were used to assess insulin resistance .Results were compared between two groups .Results Compared with non-NAFLD group, body mass index (BMI), fasting blood glucose (FBG),alanine aminotransferase (ALT),gamma-glutamyl transferase (GGT), uric acid ( UA) , triglyceride ( TG) , low density lipoprotein cholesterol ( LDL-C) ,fasting insulin ( FINS) , fasting C peptide ( FCP) , gly-cated hemoglobin a1c (HbA1c), HOMA-IR, and HOMA-C were significantly higher in the NAFLD group ( P <0.05).Logistics re-gression analysis showed that BMI , TG, GGT, and UA were risk factots for NAFLD ( P <0.05, OR =1.82, 1.53, 1.37, and 1.09 ) .Conclusions Compared patients without NAFLD , newly diagnosed type 2 diabetes patients with NAFLD present more meta-bolic disturbance, and severely insulin resistance.Obesity and the increased level of postprandial UA , triglyceridemia, and GGT might increase the risk of NAFLD in the patients with newly diagnosed type 2 diabetes mellitus .
