Successful Treatment of Five Cases of Idiopathic Central Nervous System Hypersomnia.
- Author:
In Young YOON
1
;
Do Un JEONG
Author Information
1. Yong-In Mental Hospital, Yong-In, Korea.
- Publication Type:Original Article
- Keywords:
Idiopathic central nervous system hypersomnia;
Human leukocyte antigen;
Methylphenidate
- MeSH:
Cataplexy;
Central Nervous System*;
Disorders of Excessive Somnolence*;
Hallucinations;
Histocompatibility Testing;
Humans;
Leukocytes;
Methylphenidate;
Seoul;
Sleep, REM
- From:Sleep Medicine and Psychophysiology
1997;4(1):89-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The authors studied 5 cases of idiopathic CNS hypersomnia who visited Division of Sleep Studies, Seoul National University Hospital in 1995. Detailed medical history was taken and nocturnal polysomnography(NPSG), multiple sleep latency test(MSLT)and human leukocyte antigen(HLA) typing were performed. Neither cataplexy nor hypnagogic hallucination was reported in all cases and in NPSGs, there were tendencies of increased sleep period time and decreased slow wave sleep time. In MSLT, all the subjects showed average sleep latencies less than 8 minutes without sleep-onset rapid eye movement period(SOREMP). In HLA typing, some correlation between idiopathis CNS hypersomnia and HLA DR4 was observed. in contrast to previous reports, overall treatment response with methylphenidate was remarkable. Therefore, the authors suggest that patients suspected of idiopathic CNS hypersomnia be actively evaluated and treated with rather optimistic perspective.
