Relationship between survivin/HLA classI molecules expression and survival of patients withc lear cell er nal cell carcinoma

Sulai Liu; Lin QI; Weiqing Han; Fuhua Zeng; Yu Xei; Xiongbing ZU; Jingshi Liu

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Relationship between survivin/HLA classI molecules expression and survival of patients withc lear cell er nal cell carcinoma

VernacularTitle:存活素及人类白细胞抗原I类分子与肾透明细胞癌患者预后的关系
Author: Sulai LIU ; Lin QI ; Weiqing HAN ; Fuhua ZENG ; Yu XEI ; Xiongbing ZU ; Jingshi LIU
Publication Type:Journal Article
Keywords: Clear cell renal cell carcinoma; Survivin; HLA class I molecules; Immunohisto-chemistry; Prognosis
From: Chinese Journal of Urology 2014;(7):494-497
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of survivin/Human leukocyte antigen class I ( HLA-Ⅰ) proteins and its physiological significance in clear cell renal cell carcinoma ( CCRCC ) . Methods Immunohistochemistry was used to analyze survivin/HLA-Ⅰ protein expression in 90 cases of CCRCC and 10 normal tissues to study relationships with clinical symptoms and disease prognosis . Resutl s The level of survivin protein expression was found to be significantly higher in CCRCC tissues 82.2%( 74/90) than in normal tissues( 0/10).However, the relative amount of HLA-Ⅰprotein in colorectal cancer tis-sue was also found to be significantly lower 67.8%(61/90) than in normal tissues 90%(9/10).Survivin expression was associated with tumor grade , stage,and lymph node metastasis ( P=0.000, P=0.016, and P=0.001, respectively ) .Conversely , lost HLA-Ⅰexpression did not have any associations with clinicopath-ological data (P>0.05).Survivin negative patients (25.0%, 4/16) had a higher tumor-free survival rate than patients (52.7%, 39/74)with survivin expression (P=0.037).Patients (27.6%, 8/29) with normal HLA-Ⅰlevels had a higher tumor-free survival rate than those ( 60.7%, 37/61) with reduced HLA-Ⅰlev-els (P=0.020).The univariate and multivariate analyses indicated that expression of survivin and HLA indi -vidually and in combination were independent predictors for CCRCC patient survival . Conclusions Over-expression of survivin but reduced HLA-Ⅰ expression is associated with CCRCC development and progres-sion.