The role of intrauterine growth retardation on postnatal lipid metabolism and its mechanism
10.3760/cma.j.issn.1673-4408.2014.04.003
- VernacularTitle:宫内生长迟缓对生后脂代谢的影响及其机制
- Author:
Lianhui CHEN
;
Li LIANG
- Publication Type:Journal Article
- Keywords:
Intrauterine growth retardation;
Epigenetics;
Lipid metabolism
- From:
International Journal of Pediatrics
2014;(4):347-350
- CountryChina
- Language:Chinese
-
Abstract:
Intrauterine growth retardation( IUGR) is a common complication during pregnancy. Epide-miological and clinical studies have shown that IUGR has a long-term impact on postnatal lipid metabolism. The effect of IUGR on postnatal lipid metabolism is accomplished by regulating signal pathways of fatty acid and cholesterol metabolism,which may be mediated by epigenetic modifications. Further study of these epigenetic mechanisms could lead to a novel way for prevention and treatment of adulthood diseases, including dyslipi-demia,non-alcoholic fatty liver disease and metabolic syndrome.
