Clinical efficacy of adefovir dipivoxil in treatment of decompensated cirrhosis
- VernacularTitle:阿德福韦酯治疗肝硬化失代偿期的临床疗效分析
- Author:
Zhiming LI
- Publication Type:Journal Article
- Keywords:
adefovir dipivoxil;
decompensated cirrhosis;
clinical analysis
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):153-154
- CountryChina
- Language:Chinese
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Abstract:
Objective To explore the clinical efficacy of adefovir dipivoxil in treatment of liver cirrhosis.Methods 45 cases with liver cirrhosis admitted in 302 Military Hospital of Chian in 2012 were randomly divided into experiment group(n=25)and control group(n=20).Experiment group was treated with adefovir dipivoxil,and control group was given traditional therapy.Two groups were treated for six months.Renal function,liver function and liver firosis were examined with every month,the recovery indexes of renal function between two groups were detected and compared after treatment, which was used to judge the clinical efficacy of adefovir dipivoxil. Results Before treatment,there were no significant differences in the thickness of spleen,serum indexes of portal vein,splenic vein and hepatic fibrosis between experiment group and control group.After treatment,the liver and spleen condition and liver fibrosis index including HA,LN,PCIII,IV-C in two groups were significantly improved by B ultrasound and serum detection,and the improvement degree of experimental group was significantly higher than control group(P<0.05).Conclusion Adefovir dipivoxil has better therapic efficacy in treatment of liver cirrhosis.
