Role of I-FABP in the diagnose of acute intestinal dysfunction rats with sepsis and effect of glutamine on its expression
- VernacularTitle:血清I-FABP在诊断脓毒症大鼠急性肠功能障碍中的作用及谷氨酰胺对其表达的影响
- Author:
Yunyan GUAN
;
Lijuan SHEN
;
Xiping WU
;
Qian WANG
;
Hairong WU
;
Tao XIAO
- Publication Type:Journal Article
- Keywords:
intestinal fatty acid binding protein(I-FABP);
acute intestinal dysfunction;
glutamine
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of intestinal fatty acid binding protein(I-FABP)in evaluating intestinal dysfunction of septic rats and the effect of glutamine on I-FABP expression.Methods Rats were divided into 3 groups,control group were only fed with Peptisorb,model group were fed with Peptisorb after intraperitoneal injection with E.coli endotoxin lipopolysaccharidegiven and glutamine group were added glutamine on basis of model group.The correlation between serum I-FABP level and intestinal mucosa damage index were analyzed and the concentrations of serum I-FABP in each group were observed and compared. Results The serum level of I-FABP in rats were correlated with the Chiu’s score of intestinal mucosa,mucosa thickness and villus length(P<0.05 ).Compared with control group,the concentration of serum I-FABP in model group and glutamine group were significantly increased(P<0.05),but which in glutamine group was lower than that in model group(P<0.05).Conclusions Serum I-FABP could be an non-invasive diagnosis index for evaluating acute intestinal dysfunction in septic rats.In addition,dietary glutamine supplementation may ameliorate sepsis-induced intestinal epithelial injury in rats.
