Study on osteosarcoma targeting of solid lipid nanoparticles modified with peptides specifically binding to human osteosarcoma cells
- VernacularTitle:骨肿瘤细胞特异性结合肽修饰固体脂质纳米粒的肿瘤靶向性研究
- Author:
Yuguang SONG
- Publication Type:Journal Article
- Keywords:
peptides specifically binding to osteosarcoma cells;
SLT peptides;
solid lipid nanoparticles;
drug targeting
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):53-55
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare SLT peptide modified solid lipid nanoparticles(SLT-SLNs),study on its affinity to MG63 cell and tumor targeting.Methods Cellular uptake test was used to evaluate the uptake efficiency of MG63 cell for SLT-SLNs.MG63 cell were xenografted into athymic nude mice to establish the animal model,vivo imaging was used to evaluate the targeting efficiency. Results The average particle size of SLT-SLNs was (115.7 ±8.7)nm,polydispersity coefficient was 0.12,and Zeta potential was(13 ±2.25)mV.Cellular uptake test results showed that uptaken efficiency of SLT modified SLNs by MG63 cell were 4.4 times higher than that of SLNs.The fluorescence intensity of SLT-SLNs was much stronger than that of SLNs in vivo.Conclusion The SLT peptide modified solid lipid nanoparticles has a good osteosarcoma targeting efficiency,and it might serve as a promising osteosarcoma delivery system of antitumor drugs.
