Effects of Rho-kinase inhibitor and Qiliqiangxin capsules on serum cytokines in patients with chronic heart failure
- VernacularTitle:Rho激酶抑制剂与芪苈强心胶囊对慢性心力衰竭患者细胞因子的影响
- Author:
Qingguo XU
;
Jinqiang TAN
;
Ruiju ZHANG
;
Kun LI
;
Yanmei LIU
- Publication Type:Journal Article
- Keywords:
Rho-kinase inhibitor;
Qiliqiangxin capsules;
cytokines;
chronic heart failure
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):76-78
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the short term effects of Rho-kinase inhibitor and Qiliqiangxin capsule on serum tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)levels in patients with chronic heart failure,and explore the mechanism.Methods 120 chronic heart failure patients received conventional treatment for 4 weeks were divided into blank control group(Group A,n=30),Rho-kinase inhibitor treated group(Group B,n=30), Qiliqiangxin capsules-treated group (Group C,n =30 ),and the other 30 cases were treated with Rho-kinase inhibitor combined with Qiliqiangxin capsules(GroupD,n=30).TNF-α,IL-6 and BNP were measured and cardiac function was evaluated before and after treatment.The difference between 4 groups was analyzed. Results After treatment,the levels of TNF-α,IL-6,BNP in the observation group were lower than that in the control group.The difference was statistically significant(P<0.05 ).The levels of TNF-α,IL-6,BNP in the D group were lower than that in the B and C group.The difference was statistically significant(P<0.05 ).Conclusion Rho-kinase inhibitor combined with Qiliqiangxin capsule can improve cardiac function and reduce levels of serum cytokines associated with chronic heart failure,which is conducive to the treatment of chronic heart failure.
