Type-2 innate lymphoid cells in bronchial asthma
10.3760/cma.j.issn.1673-4408.2014.04.011
- VernacularTitle:Ⅱ型固有淋巴细胞在支气管哮喘中的研究现状
- Author:
Chaofeng XING
;
Jun QIAN
- Publication Type:Journal Article
- Keywords:
Type-2 innate lymphocyte cells;
Asthma
- From:
International Journal of Pediatrics
2014;(4):376-379
- CountryChina
- Language:Chinese
-
Abstract:
Type-2 innate lymphoid cells ( ILC2 ) is a new member of the innate lymphoid cell family which has been recently discovered. These cell arise from lymphoid progenitors in the bone marrow and,under the control of the transcriptional regulators and Gata3,producing IL-5,IL-9 and IL-13 is a sign of the matura-tion. These cells are critical components of the innate immune response to parasitic worm infections and have al-so been implicated in the pathogenesis of asthma. This paper summarizes the role of ILC2 in the pathogenesis of asthma and its therapy research progress.
