Inhibitory effects of cetylpyridinium chloride buccal tablets on dental plaque

VernacularTitle:西吡氯铵含片对牙菌斑抑制效果的临床试验研究
Author: Yuanyuan TAN ; Jianying ZHANG ; Guanrong ZHANG ; Yun FU
Publication Type:Journal Article
Keywords: Cetylpyridinium chloride buccal tablets; Plaque index; Bleeding index; TNF-α; IL-1β
From: Journal of Practical Stomatology 2014;(4):538-542
CountryChina
Language:Chinese
Abstract: Objective:To investigate the effects of cetylpyridinium chloride buccal tablets(CCBT)on dental plaque control.Meth-ods:60 patients with gingivitis,mild or moderate,or chronic periodontitis were divided into control group(without drug treatment), CCBT group (treated with CCBT)and CHX group (treated with compound chlorhexidine gargle)according to the randomized con-trolled single-blind principle.Quigley-Hein plaque index (PI)and bleeding index (BI)of the subjects were recorded,tumor necro-sis factor (TNF-α)and interleukin (IL-1β)in gingival crevicular fluid (GCF)were measured by ELISA before and after 2 weeks'trial.Results:After 2-week treatment,PI and BI in CCBT and CHX groups decreased(P<0.01);TNF-αin GCF decreased(P<0.05),IL-1βcontent was not changed.The changes of PI and BI were not significant between CCBT and CHX groups(P>0.05). In control group PI was decreased(P<0.05),other measurements were not changed(P>005).Conclusion:CCBT is effective in inhibiting plaque accumulation and decreasing GCF TNF-αlevel.