Clinical analysis of low dose thalidomide combined with conventional chemotherapy in the treatment of multiple myeloma
- VernacularTitle:低剂量沙利度胺联合常规化疗治疗多发性骨髓瘤的临床分析
- Author:
Xuejuan TANG
;
Li REN
- Publication Type:Journal Article
- Keywords:
thalidomide;
conventional chemotherapy;
multiple myeloma;
efficacy
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):113-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of low dose thalidomide combined with chemotherapy in treatment of multiple myeloma(MM)and the clinical curative effect of the treatment method.Methods From June 2010 to June 2012,80 patients were diagnosed with multiple myeloma as the research object in Traditional Chinese Medicine Hospital of Haining,randomly divided into control group and observation group,with 40 cases in each group.The control group adopted conventional chemotherapy,the observation group were given low dose thalidomide combined with conventional chemotherapy.The clinical effect and adverse drug reactions were compared. Results The total effective rate of observation group (87.5%)was significantly higher than that of control group(65.0%)(P<0.05).The adverse reactions were 87.5%(35/40)in observation group and 100.0%(40/40)in control group,there was no significant difference between the two groups.The mean progression-free survival(PFS)and overall survival(OS)in observation group(5.5 ±1.2 months;1 1.5 ±2.4 months)were higher than those in control group(3.7 ±0.8 months;8.5 ±1.3 months)(P<0.05 ). Conclusion Low dose thalidomide combined with conventional chemotherapy in the treatment of multiple myeloma can improve clinical effect and decrease recurrence rate,with high safety and less adverse reactions.
