Research progress in protective effects and mechanisms of Ligustrazine on cerebra,spinal cord injury
- VernacularTitle:川芎嗪对脑、脊髓损伤的保护作用及其机制研究进展
- Author:
Dandan SUN
;
Danqiao WANG
- Publication Type:Journal Article
- Keywords:
Ligustrazine;
cerebra injury;
spinal cord injury;
mechanism
- From:
Chinese Journal of Biochemical Pharmaceutics
2014;37(4):179-183
- CountryChina
- Language:Chinese
-
Abstract:
Ligustrazine which has extensive pharmacological effects has been clinically used in the treatment of cardiovascular and cerebrovascular diseases,respiratory diseases,urinary diseases,cirrhosis,cancer,etc.Research of protective effects of Ligustrazine on spinal cord injury has recently increased year by year.Numerous clinical trials and animal experiments suggest that Ligustrazine can play a role on ischemic cerebrovascular disease, degenerative brain disease,epilepsy,spinal cord injury and so on,whose main mechanisms include inhibiting of apoptosis and inflammation,enhancing the body’s antioxidant level,improving hemorheology,increasing expression of neurofilament protein and neurotrophic factors,and regulating balance of the ion intracellular and extracellular.Through consulting the relevant literature since 2003,this article reviews the protective roles and mechanisms of Ligustrazine on cerebra and spinal cord injury for the past 10 years.
