GnIH/GPR147 and Kisspeptin/GPR54 in puberty onset
10.3760/cma.j.issn.1673-4408.2014.04.016
- VernacularTitle:GnIH/GPR147和Kisspeptin/GPR54与青春发育启动
- Author:
Suhuan LI
;
Yonghong WANG
- Publication Type:Journal Article
- Keywords:
GnIH/GPR147;
Kisspeptin/GPR54;
GnRH;
Puberty
- From:
International Journal of Pediatrics
2014;(4):394-397
- CountryChina
- Language:Chinese
-
Abstract:
The initiation of puberty is associated with the hypothalamus-pituitary-gonadal( HPG) axis. The activation of gonadotropin-releasing hormone( GnRH) is the key factor in the initiation of puberty. The initi-ation of puberty is a complicated process,GnRH is under the influence of many associated neuropeptides. Re-cently,the studies have found that GnIH and Kisspeptin can respectively inhibit and promote the hypothalamus GnRH secretion of mammals,indicating that GnIH and Kisspeptin on regulation of reproductive endocrine axis play very important roles. Therefore,GnIH/GPR147 and Kisspeptin/GPR54 pathways may be closely associated with the initiation of puberty.
