Molecular mechanisms of endothelial hyperpermeability in sepsis
10.3760/cma.j.issn.1673-4408.2014.04.017
- VernacularTitle:脓毒症时内皮细胞高渗透性的分子机制
- Author:
Chunyan YANG
;
Ping XU
;
Xianmei LU
- Publication Type:Journal Article
- Keywords:
Endothelial cell;
Microvascular permeability;
Signal transduction;
Sepsis
- From:
International Journal of Pediatrics
2014;(4):398-400
- CountryChina
- Language:Chinese
-
Abstract:
There is endothelial hyperpermeability in sepsis,trauma,ischaemia-reperfusion injury,acute respiratory distress syndrome and thrombosis,while an important mechanism underlying this process is increased paracellular leakage of plasma fluid and protein because of cytoskeleton contration under the role of histamine, thrombin,vascular endothelial growth factor and activated neutrophil. Structural changes initiate with agonist-re-ceptor binding,followed by activation of intracellular signalling molecules,then phosphorylate alter the hyperme-ability of cell-cell adhesion. Targeting key signalling molecules that mediate endothelial-junction-cytoskeleton dissociation demonstrates a therapeutic potential to improve vascular barrier function during inflammatory injury.
