Changes of serum cytokine levels in patients with hand-foot-and-mouth disease and therapeutic effects of intravenous immunoglobulin
10.3760/cma.j.issn.1673-4408.2014.04.026
- VernacularTitle:手足口病患儿血清细胞因子水平变化及免疫球蛋白治疗效果分析
- Author:
Tongzeng LI
;
Taiyi JIANG
;
Lianchun LIANG
- Publication Type:Journal Article
- Keywords:
Hand-foot-and-mouth disease;
Cytokines;
Intravenous immunoglobulin;
Clinical analysis
- From:
International Journal of Pediatrics
2014;(4):427-430
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of cytokines in hand-foot-and-mouth disease( HFMD) patients.Methods Retrospective analysis was performed on the clinical data of 262 cases of HFMD.All 262 children with HFMD were divided into two groups:severe cases and non-severe cases.Five cytokines( IL-2,IL-6,IL-10,TNF-αand IFN-γ) simultaneously were detected by luminex multiplexed assays.Results There were 153 severe cases and 109 non-severe cases,The results showed that the levels of IL-2,IL-6,IL-10,TNF-αin severe cases were higher than non-severe cases,and the differences were significant (18.02 ng/L vs 22.71ng/L, 28.42 ng/L vs 53.76 ng/L,17.92 ng/L vs 42.37 ng/L,102.29 ng/L vs 207.99 ng/L,P<0.05 ) .No significant difference of IFN-γlevel was found between the two groups(325.51 vs 373.78 ng/L,P>0.05).In 40 critical cases,plasma levels of IL-2,IL-6,IL-10,TNF-α,and IFN-γwere significantly decreased after administration of intravenous immunoglobulin( P<0.05 ) .Conclusion Some cytokines increase in children with severe HFMD, indicating that inflammatory and anti-inflammatory reaction may play importent roles in the pathogenesis of se-vere HFMD.The findings suggest that intravenous immunoglobulin might play a therapeutic role in severe HFMD.
