Clinicopathological features and multivariate analysis of prognostic factors for patients with gallbladder cancer
10.3760/cma.j.issn.1007-631X.2014.07.004
- VernacularTitle:胆囊癌临床病理特点及预后的多因素分析
- Author:
Jiabin WANG
;
Lixia LIU
;
Gang WANG
;
Honggen QIU
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2014;29(7):499-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical pathologic characteristics of gallbladder cancer and prognostic factors for patients with gallbladder cancer.Methods We retrospectively reviewed 108 patients diagnosed pathologically with gallbladder cancer and treated in HuBei Three Gorges Polytechnic Medical College,Yichang Central People's Hospital and Yichang First People's Hospital from January 2003 to December 2012.Kaplan-Meier method was used to estimate survival.The association between the clinicopathologic characteristic and the prognosis in gallbladder cancer patients was assessed using Log-rank test.Cox proportional hazards model was used to determine independent risk factors.Results All patients were followed up from 3 to 102 months,the median follow-up time was 46 months.There were 77 deaths (71.3％),31 patients are alive.Survival time after operation was from 4-98 months.The mean and the median survival time were 28.4 months and 17 months respectively.The 1,2,3 and 5-year overall survival rates were 54.2％,37.5％,31.3％ and 21.6％.Multivariate analysis indicated independent risk factors were such as incidental gallbladder cancer,lymph node metastasis,poor differentiation.Conclusions Gallbladder cancer is a malignancy with poor prognosis.Incidental gallbladder cancer,lymph node metastasis,tumor poor differentiation are independent risk factors.
