A study on the relationship between pregnant, neonatal risk factors and childhood asthma
10.3969/j.issn.1000-3606.2014.08.005
- VernacularTitle:母孕期及新生儿期危险因素与儿童支气管哮喘的关系
- Author:
Chunmei JIA
;
Junqing WANG
;
Xiaoqin CHEN
;
Dongmei WANG
;
Cairong JIANG
;
Li JIANG
- Publication Type:Journal Article
- Keywords:
asthma;
risk factor;
child
- From:
Journal of Clinical Pediatrics
2014;(8):716-719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between childhood asthma and pregnant and neonatal risk factors, thus provide evidence for early prevention of childhood asthma. Methods 162 children diagnosed asthma and 213 healthy children in pediatric outpatient and the inpatient services of our hospital who was born and living in Baotou city were retrospectively analyzed. The pregnancy related factors (parity, fever during pregnancy, pregnancy-induced hypertension syndrome, gestational diabetes mellitus, history of overdose in early-pregnancy) and the neonatal period related factors (surface defects, asphyxia, rough placenta, birth weight, number of fetus during this pregnancy, gestational age, premature birth, cesarean section) were investigated. The sex and age showed no signiifcance between childhood asthma and control group. Results Eight pregnant and neonatal factors (fever during pregnancy, pregnancy-induced hypertension syndrome, history of overdose in early-pregnancy, surface defects, asphyxia, rough placenta, birth weight, premature birth, cesarean section) showed signiifcant difference between the two groups (P<0.05). Multifactor regression analysis found fever during pregnancy (OR=9.43, 95%CI:3.08~28.82), rough placenta (OR=2.15, 95%CI:1.29~3.59), premature birth (OR=5.16, 95%CI:1.53~17.39) and cesarean section (OR=4.05, 95%CI:2.40~6.86)are independent risk factors for childhood asthma. Conclusions Fever during pregnancy, abnormal placenta;premature birth and cesarean section are likely risk factors of childhood asthma.
