Clinical value of detecting serum N-terminal pro-brain natriuretic peptide and cardiac troponin I in children with severe pneumonia
10.3969/j.issn.1000-3606.2014.08.007
- VernacularTitle:重症肺炎患儿血清N末端脑钠素原和肌钙蛋白I水平变化及意义
- Author:
Caizhi HUANG
;
Liya MO
;
Juan YANG
;
Yongchao DENG
;
Aiguo LI
- Publication Type:Journal Article
- Keywords:
severe pneumonia;
N-terminal pro-brain natriuretic peptide;
cardiac troponin I;
child
- From:
Journal of Clinical Pediatrics
2014;(8):724-726
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of serum N-terminal pro-brain natriuretic peptide (NT-ProBNP) and cardiac troponin I (cTnI) levels in children with severe pneumonia. Methods A total of 72 children with severe pneumonia in pediatric intensive care unit were divided into heart failure (HF) group and non-HF group according to the occurrence of heart failure, and 30 healthy children were selected as control group. Serum NT-ProBNP and cTnI levels were detected and analyzed. Results Compared with control group, NT-ProBNP and cTnI levels were signiifcantly higher (P<0.01) in HF and non-HF group. The levels of NT-ProBNP and cTnI in HFgroup were both signiifcantly higher (P<0.01) than that in non-HFgroup. Serum NT-ProBNP level was positively related to the level of cTnI(P=0.000) in children with severe pneumonia. The abnormal rate of cTnI in HF group was significantly higher (P=0.037) than that in non-HFgroup. The difference of the abnormal rate of NT-ProBNP between the two groups was not signiifcant (P=0.375), however, the abnormal rate of NT-ProBNP was signiifcantly higher (P=0.036) than that of cTnI in non-HF group. Conclusions There was obvious myocardial damage in children with severe pneumonia. NT-ProBNP and cTnI could be important serological markers to assist diagnosis of myocardial damage and its severity.
