Observation of thrombus aspiration combined tirofiban on heart function and prognosis in patients of acute myocardial infarction with thrombosis
10.3969/j.issn.1004-8812.2014.09.007
- VernacularTitle:血栓抽吸联合替罗非班对急性心肌梗死血栓病变患者心功能及预后的影响
- Author:
Lixin WANG
;
Jianbin WANG
;
Li YANG
;
Fujun LI
;
Yu ZHAO
;
Xiaolei HE
;
Cuiping YAN
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Angioplasty;
Percutaneous coronary intervention;
Thrombus aspiration
- From:
Chinese Journal of Interventional Cardiology
2014;(9):574-577
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognestic effect of thrombus aspiration combined tirofiban in patients of acute myocardial infarction. Methods 372 patients with acute ST segment elevation myocardial infarction were randomly divided into the observation group (n=183) and the control group (n=189). Patients in the observation group received thrombus aspiration combined tirofiban additional to conventional treatment, and cases in the control group received routine treatment. The curative effect, postoperative complications and adverse reactions were compared between the 2 groups. Results The postoperative TIMI classⅢperfusion was achieved in 152 cases (83.1%) in the observation group and 140 cases (74.1%) in the control group (P < 0.05). The left heart ejection fraction of the observation group on 7 and 30 days after surgery was (60.4±6.1)%and (64.3±5.6)%respectively which was higher than the control group with (52.4±5.9)% and (55.4±5.7)% on 7 and 30 days respectively (P < 0.05). Bleeding events were recorded in 36 cases(19.7%) in the observation group rensus 26 versus (13.8%) in the control group (P>0.05). MACE reorded within 30 d post operation was 10 cases(5.5%) in the observation group and 22 cases (11.6%) in the control group (P < 0.05). No thrombocytopenia recorded in both groups. Conclusions Thrombus aspiration combined tirofiban for patients with acute myocardial infarction during PCI can improve the postoperative coronary artery perfusion, left ventricular ejection function and reduce the incidence of MACE within 30 days.
