Preparation of Novel Biocompatible Macromolecular Magnetic Resonance Imaging Contrast Agent
10.11895/j.issn.0253-3820.140447
- VernacularTitle:新型生物相容性大分子磁共振成像造影剂的性质研究
- Author:
Yan XIAO
;
Rong XUE
;
Youyang ZHAN
;
Chenli QI
;
Tianyan YOU
;
Xiaojing LI
;
Fengkui PEI
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Polyaminoacid;
Biocompatibility;
Liver-specifity
- From:
Chinese Journal of Analytical Chemistry
2014;(10):1421-1426
- CountryChina
- Language:Chinese
-
Abstract:
Poly ( aspartic acid-co-leucine) was synthesized, modified via ethylenediamine, conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and finally chelated with gadoliniumⅢ, yielding PL-A2-DOTA-Gd. The T1-relaxivity (15. 3 mmol-1 ·L·s-1 ) of PL-A2-DOTA-Gd was 2. 6 times than that of Gd-DOTA (5. 8 mmol-1·L·s-1) in D2O. The results of magnetic resonance imaging experiments showed significant enhancement in the rat liver after intravenous administration of PL-A2-DOTA-Gd, which persisted longer than Gd-DOTA. The mean percentage enhancements of liver parenchyma were 65. 1%±5. 2%and 21. 3%±4. 9%, for PL-A2-DOTA-Gd and Gd-DOTA, respectively.
