Implication of serum immunoglobulins and C3 in disease condition evaluation and prognosis of childhood primary nephrotic syndrome
10.3969/j.issn.1671-8348.2014.26.008
- VernacularTitle:免疫球蛋白及C3对儿童原发性肾病综合征病情评估及预后的意义
- Author:
Qiu LI
;
Haiyan CHEN
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
child;
age;
immunoglobulin G;
complement C3;
immunoglobulin A;
immunoglobulin M;
immu-noglobulin E;
prognosis
- From:
Chongqing Medicine
2014;(26):3431-3433
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the clinical significance of serum immunoglobulins and C3 at the initial episode on the treat-ment and prognosis of childhood primary nephrotic syndrome(PNS) .Methods 426 children patients with first episode of PNS ad-mitted to the nephrology department of our hospital from January 1 ,2003 to December 30 ,2012 were retrospectively analyzed .The clinical data were collected for conducting the analysis on the immuneglobulins and C 3 levels in different age groups ,clinical classifi-cation ,hormone response ,recurrence ,prognosis and correlation among various pathological types .Results (1)Compared with the healthy children ,the peripheral blood IgG level in childhood PNS was significantly decreased ,while the IgM and IgE level were sig-nificantly increased .(2)The IgE level in steroid-sensitive nephrotic syndrome(SSNS) was higher than that in steroid-resistant ne-phrotic syndrome(SRNS);which in frequent recurrence nephrotic syndrome was higher than that in non-recurrence nephrotic syn-drome .(3) The C3 level in the PNS children patients aged over 1 years and nephritis nephrotic syndrome(NNS) was lower than that in simple nephrotic syndrome(SNS) .Conclusion PNS is correlated with the immune dysfunction .Serum IgE level increase clinically manifests by the steroid sensitivity and frequent relapse ;the lower the C3 level ,the poorer the prognosis .
