Efficacy observation of sequential plasma perfusion of low dose plasma exchange in patients with acute on chronic liver failure
10.3969/j.issn.1671-8348.2014.25.006
- VernacularTitle:小剂量血浆置换序贯血浆灌流对慢加急性肝衰竭患者疗效观察
- Author:
Gang WU
;
Wen CHEN
;
Cunliang DENG
;
Li TANG
;
Bo QIN
- Publication Type:Journal Article
- Keywords:
plasma exchange;
perfusion;
acute on chronic liver failure;
treatment outcome
- From:
Chongqing Medicine
2014;(25):3281-3283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of sequential plasma perfusion of low dose plasma exchange in the pa-tients with acute on chronic liver failure (ACLF).Methods The patients with HBV related ACLF in the infection department of the Affiliated Hospital of Luzhou Medical College were divided into the plasma exchange therapy group (group A,n=114)and the low dose plasma exchange sequential plasma perfusion therapy group (group B,n=144).The group A was treated only by plasma exchange of fresh frozen plasma 2 400 mL;while the group B adopted the sequential plasma perfusion of plasma exchange,with fresh frozen plasma dosage of 1 400 mL.The changes of the liver and renal function,coagulation function and electrolyte indicators were observed in the two groups.The differences in the clinical effects and adverse reactions were compared between the two groups.Results The serum levels of ALT,TBIL and INR after treatment in the two groups were significant decreased than before treatment(P<0.05);ALB and PTA were significantly improved compared with before treatment(P<0.05);there were no signif-icant differences in serum levels of CRE,K+ and Na+ between before and after treatment.The changes of various indexes before and after treatment had no statistical differences between the two groups.The total effective rate and the mortality at 24 weeks in the group B was 66.66% and 47.22% respectively,which had no statistical differences compared with the group A.The total oc-currence rate of adverse reactions in the group B was 23.75%,which was significant lower than 35.26% in the group A with statis-tical difference (P=0.011).Conclusion Sequential plasma perfusion of plasma exchange has better clinical effect and few adverse reactions for treating the patients with ACLF,which can reduce the plasma dosage significantly.
