Efficacy observation on Uremic Clearance Granule combined with ARB or ACEI for treating massive proteinuria in patients with diabetic nephropathy
10.3969/j.issn.1671-8348.2014.26.010
- VernacularTitle:尿毒清联合 ARB／ACEI治疗糖尿病肾病大量蛋白尿的疗效观察
- Author:
Qinjin HU
;
Zhencheng YAN
- Publication Type:Journal Article
- Keywords:
Uremic Clearance Granule;
diabetic nephropathies;
angiotensin-converting enzyme inhibitors;
angiotensin receptor blockers
- From:
Chongqing Medicine
2014;(26):3436-3438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Uremic Clearance Granule combined with angiotensin receptor blockers (ARB) or angiotensin converting enzyme inhibitors (ACEI) in treating different period of diabetic nephropathy (DN ) .Methods 46 patients with DN were divided into the control group and the treatment group ,23 cases in each group .The two groups were given the rou-tine hypoglycemic therapy .The control group was treated with ACEI or ARB ,while the treatment group was given Uremic Clear-ance Granule 5 g each time ,four times daily for successive 4 weeks .Then the indexes of serum creatinine ,blood urea nitrogen ,cysta-tin-C ,microalbumin and 24 h urine total protein at 24 h before and after treatment were observed .Results The microalbumin and 24 h urine total protein after treatment in the two groups were reduced compared with before treatment (P<0 .01) .In the patients with the stage Ⅲ of DN ,the urine protein decrease after treatment had no statistical difference between the two groups (P>0 .05) . In the patients with the stage Ⅳ of DN ,on the basis of ACEI or ARB adding Uremic Clearance Granule could significantly decrease the urine protein(P<0 .05) .Conclusion ACEI or ARB combined with Uremic Clearance Granule has definite effect for treating massive proteinuria of DN .
