Research on effect of neutrophil elastase inhibitor on blood-brain barrier permeability and cerebral edema in TBI rats
10.3969/j.issn.1671-8348.2014.26.018
- VernacularTitle:中性粒细胞弹性蛋白酶抑制剂对颅脑创伤大鼠血脑屏障通透性和脑水肿的影响
- Author:
Hai SU
;
Zulu SU
;
Xuenong HE
;
Changlong ZHOU
;
Hao CHEN
;
Xiaohui XIA
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
craniocerebral trauma;
proteinase inhibitory proteins,secretory;
sivelestat sodium;
brain edema
- From:
Chongqing Medicine
2014;(26):3458-3460
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of neutrophil elastase (NE) inhibitor on the blood-brain barrier(BBB) permeabili-ty and hydrocephalus in rats with traumatic brain injury (TBI) .Methods 99 SD rats were randomly divided into the control group , the TBI group and the intervention group(dividing into 5 sub-groups:6 ,24 ,48 ,72 ,168 h) .The hydraulic impact model of rats was duplicated .Sivelestat sodium was given in the intervention group .The NE concentration in the brain tissue ,BBB permeability and brain water content were detected in each group and performed the comparative analysis .Results The NE concentration in the brain tissue ,BBB permeability and brain water content at each timepoint in the TBI group and the intervention groups were higher than those in the control group .The NE concentration at 24 ,48 ,72 ,168 h in the intervention group was lower than that in the TBI group .The BBB permeability and the brain water content at 48 ,72 ,168 h in the intervention group were lower than those in the TBI group(P<0 .05) .Conclusion Sivelestat sodium can inhibit the NE release in TBI rat brain tissue ,reduce the BBB permeability and the occurrence of hydrocephalus ,which indicating that sivelestat sodium has the protective effect on TBI secondary lesion in rat .
